Author

Jonathan Cramer

Heinrich Heine University DüsseldorfORCID 0000-0001-9869-5645Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra Großdorf· 2 shared Christian GorzelannyiD· 2 shared Nick RähseiD· 2 shared Önder KurçiD· 2 shared Prof. Dr. Holger GohlkeiD· 2 shared Alexander N.R. WeberiD· 1 shared Anayancy Osorio‐MadrazoiD· 1 shared Bruno Maria MoerschbacheriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Alexandra Großdorf

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Dual Carbohydrate Recognition by the Chitinase-like Protein CHI3L1 Through Distinct Glycosaminoglycan and Chitin-Binding Interfaces

Önder Kurç, Nick Rähse, Mohanraj Gopalswamy, Alexandra Großdorf, Christian Gorzelanny, Jonathan Cramer, Holger Gohlke

This study identifies two distinct carbohydrate-binding sites on CHI3L1, showing that chitin oligosaccharides and glycosaminoglycans bind to separate sites with different affinities and regulatory effects.

bioRxiv · Sep 21, 2026 · PreprintBiophysics

Chitinase-3-like protein 1 decodes chitosan acetylation patterns into toll-like receptor 2 signaling through heparan sulfate

Alexandra Großdorf, Sina Nabil, Carlotta Imelmann, Margareta J. Hellmann, Jurij Froese, Ehab El‐Awaad, Tuan Anh Tran, Stefan Cord‐Landwehr, Nick Rähse, Önder Kurç, Fuzhu Yang, Hung-Yu Chen, Evelyne Gout, Gabriela Rosca, Marion Kusche‐Gullberg, , Christian Gorzelanny

This study shows CHI3L1 interacts with chitosan and heparan sulfate to activate TLR2 signaling, revealing HS as a co-receptor for CHI3L1 and its role in inflammation.

bioRxiv · Jun 16, 2026 · PreprintMolecular Biology