Vivek Srinivas

This study shows that host oxidative stress primes Mycobacterium tuberculosis for rapid antibiotic resistance evolution by creating permissive genomic backgrounds that accelerate resistance mutations.

This study identifies MtrA as a critical regulator of peptidoglycan cleavage in Mtb, essential for survival under acidic stress and a potential drug target.

This study shows that disrupting the ArcA regulatory network in TetR E. coli increases tetracycline susceptibility, suggesting a strategy to re-sensitize AMR pathogens.

The paper identifies a six-state genetic program in Mycobacterium tuberculosis that enables entry into and exit from hypoxia-induced dormancy through high-resolution transcriptional time-course analysis.