Jordan S. Farrell

Connexin 40 deficiency alters the temporal profile of postictal oxygen dynamics following focal seizures.

This study shows that Cx40 deficiency changes the timing of oxygen recovery after seizures without affecting seizure duration.

Hippocampal microcircuits constrain the generation of epileptiform activity

This study shows that microcircuit-specific inhibition in the hippocampus can drive epileptiform activity, highlighting the role of cellular-level organization in epilepsy.

FMR1 reduction alters cellular and circuit properties in human cortex

This study reduces FMR1 expression in human cortical slices to model Fragile X syndrome, revealing cell type-specific transcriptomic and electrophysiological changes not observed in mouse models.

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

Toothy: an interactive platform for dentate spike curation

Toothy is an open-source tool for detecting and classifying dentate spikes in electrophysiological recordings, supporting reproducibility and comparative analysis with sharp wave-ripples.

Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia

This study shows that blocking postictal hypoxia prevents SUDEP in mice by preventing seizure-induced vasoconstriction.

A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia

This study investigates the role of postictal hypoperfusion/hypoxia in memory impairments after seizures, finding that synaptic plasticity is specifically affected while other network functions remain intact.