Chenxiang Lin

This study uses DNA-origami rings to investigate FG-Nup interactions and their impact on NPC function, revealing how sequence and post-translational modifications affect protein behavior.

This paper introduces DNA nanorings to dynamically control membrane tension in sub-100 nm liposomes, enabling controlled mechanical stress and molecular cargo release.

The paper develops a DNA nanodevice to apply controlled forces to proteins, demonstrating its use in studying mechanosensitive protein interactions and identifying novel tension-dependent binders.

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

The paper develops a DNA-based molecular clamp to apply tension to proteins and study their interactions and structure under force.

The paper proposes lipid osmosis as a mechanism for lipid flow driven by membrane protein density and tension differences, and explores its biological functions and testing methods.

This paper demonstrates DNA clamps that, when triggered by specific signals, induce membrane tubulation in GUVs by releasing stored energy through conformational changes.

The paper introduces a DNA-origami NanoTrap to study diffusion barriers formed by FG-nups and finds that motif type, density, and arrangement are critical for barrier effectiveness.