Author

Chaya Sussman

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:imaging· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jaime L. HookiD· 5 shared Sarah K. MooreiD· 4 shared Deebly Chavez· 3 shared Jaymin J. KathiriyaiD· 3 shared Sayahi SuthakaraniD· 3 shared Stephanie TangiD· 3 shared Clemente J. BrittoiD· 2 shared Jimmy ZhangiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCell Biology

Jaime L. HookORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dysplastic Alveolar Basaloid Cells Provide a Protective Barrier via KRT17-Stratifin Complex during Chronic Fibrosis

Isha R Sahasrabudhe, Xinran Ma, Stefano A. Iantorno, Tristan Tran, Sachin D'Souza, Chaya Sussman, Dakota L. Jones, Mauer Biscotti, Ivy Cao, Jeremy B. Katzen, Maria Ciocca Basil, Jaime L. Hook, Konstantinos–Dionysios Alysandratos, Jaymin J. Kathiriya

The paper identifies KRT17-Stratifin complex as a protective barrier in dysplastic alveolar basaloid cells during chronic fibrosis, revealing mechanisms of alveolar metaplasia and its functional relevance.

bioRxiv · Oct 30, 2026 · PreprintCell Biology

Lung hypoperfusion stimulates liquid absorption in alveoli

J Zhang, Deebly Chavez, Sayahi Suthakaran, Chaya Sussman, Stephanie Tang, Sarah K. Moore, Clemente J. Britto, Jaymin J. Kathiriya, Hooman D. Poor, Jaime L. Hook

This study shows lung hypoperfusion reverses alveolar liquid transport from secretion to absorption through mechanical signals and specific ion channels.

bioRxiv · Jul 3, 2026 · PreprintPhysiology

Multivalent Nanobodies for Potent and Broad Neutralization of Staphylococcus aureus Toxins

Y S Kim, Nicholas R. Walton, Wei Huang, Madison Lee, Yufei Xiang, Zhe Sang, Chaya Sussman, Sarah K. Moore, Derek J. Taylor, K Chen, Jaime L. Hook, John K. McCormick, Yi Shi

This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.

Nature Communications · May 20, 2026Peer-reviewedMicrobiology

Notch mediates non-regenerative alveolar repair after staphylococcal lung injury

Sarah K. Moore, Stephanie Tang, Deebly Chavez, Sayahi Suthakaran, Chaya Sussman, Jimmy Zhang, Jaime L. Hook

This study identifies Notch-mediated junctional protein reassembly as a mechanism for non-regenerative alveolar barrier repair after Staphylococcus aureus lung injury.

bioRxiv · Feb 5, 2026 · PreprintMolecular Biology

CFTR function in alveolar type 1 cells drives lung liquid secretion and host defense

Sayahi Suthakaran, Sonya Homami, Deebly Chavez, Stephanie Tang, Sarah K. Moore, Chaya Sussman, Jimmy Zhang, Clemente J. Britto, Alice S. Prince, Alison J. May, Jaymin J. Kathiriya, Jaime L. Hook

The paper identifies CFTR function in alveolar type 1 cells as critical for lung liquid secretion and host defense against pathogens.

bioRxiv · Mar 25, 2025 · PreprintCell Biology