Jason Daniel Buenrostro

The paper uses gene expression data and GWAS summary statistics to identify disease-relevant tissues and cell types by detecting heritability enrichments in gene-specific expression regions.

This study uses ATAC-seq in C. elegans to identify dynamic chromatin accessibility changes, revealing novel enhancers and a regulatory factor involved in development.

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

chromVAR analyzes sparse scATAC-seq data to estimate motif-associated accessibility changes and cluster profiles while controlling technical biases.

The paper uses single-cell chromatin accessibility to map the continuous regulatory variation in human hematopoietic differentiation and identifies epigenomic heterogeneity within cell populations.