Author

Michał Brouze

International Institute of Molecular and Cell BiologyORCID 0000-0001-9959-4985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrzej DziembowskiiD· 3 shared Seweryn MroczekiD· 3 shared Ewa BorsukiD· 2 shared Jakub GruchotaiD· 2 shared Marcin SzpilaiD· 2 shared Olga GewartowskaiD· 2 shared Paweł Szczepan KrawczykiD· 2 shared Wiktor AntczakiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersMolecular Biology

Andrzej DziembowskiORCID

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3 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedDec 2, 2025

PolyA tail segmentation improves the stability of the template DNA and increases the translatability of in vitro transcribed mRNA

Tomasz Śpiewla, Karol Czubak, Zofia Pilch…·Joanna Kowalska

The paper develops segmented polyA tail designs to improve DNA stability and mRNA translatability, finding that longer segmented tails significantly enhance protein production.

10 citations

experimental assay

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Molecular BiologyRNAPeer-reviewedFeb 7, 2025

DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.

Michał Brouze, Marcin Szpila, Areta M. Czerwińska…·Andrzej Dziembowski

This study shows DIS3L is essential for mouse embryo development but not cell viability, as its absence causes severe embryo degeneration and impaired protein synthesis without affecting cell survival or transcriptome levels.

4 citations

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintAug 1, 2023

Polyadenylation of mRNAs encoding secreted proteins by TENT5 family of enzymes is essential for gametogenesis in mice.

Michał Brouze, Agnieszka Czarnocka-Cieciura, Olga Gewartowska…·Andrzej Dziembowski

1 citation

mousebulk RNA-seq

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