DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
Michał Brouze, Marcin Szpila, Areta M. Czerwińska, Wiktor Antczak, Seweryn Mroczek, Tomasz M. Kuliński, Anna Hojka-Osińska, Dominik Cysewski, Olga Gewartowska, Dorota Adamska, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski
This study shows DIS3L is essential for mouse embryo development but not cell viability, as its absence causes severe embryo degeneration and impaired protein synthesis without affecting cell survival or transcriptome levels.
RNA · Feb 7, 2025Peer-reviewedMolecular Biology