Author

Koodali T Nishant

Indian Institute of Science Education and Research ThiruvananthapuramORCID 0000-0002-4342-7501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 5 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:yeast· 5 Research Focus:benchmarking· 3 Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

Parijat ChakrabortyiD· 3 shared V. P. Ajith· 3 shared Akira ShinoharaiD· 2 shared Aline Rodrigues-PrauseiD· 2 shared Carol M. ManhartiD· 2 shared Eric AlaniiD· 2 shared Ewa P. MalciD· 2 shared Juan Lucas ArguesoiD· 2 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenetics

Parijat ChakrabortyORCID

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6 papers

Recent·Most cited

Exo1-protected DNA nicks direct crossover formation in meiosis

Michael Gioia, Lisette Payero, Gianno Pannafino, Jun Jie Chen, Sagar Salim, Ghanim Fajith, Amamah F. Farnaz, Sherikat Momoh, Michelle K. Scotland, Vandana Raghavan, Carol M. Manhart, Akira Shinohara, Koodali T Nishant, Eric Alani

This study shows Exo1 protects DNA nicks to promote meiotic crossover formation and distribution in budding yeast.

bioRxiv · Aug 29, 2021 · PreprintMolecular Biology

Characterization of systemic genomic instability in budding yeast

Nadia M. V. Sampaio, V. P. Ajith, Ruth A. Watson, Lydia R. Heasley, Parijat Chakraborty, Aline Rodrigues-Prause, Ewa P. Malc, Piotr A. Mieczkowski, Koodali T Nishant, Juan Lucas Argueso

The paper characterizes bursts of genome-wide loss-of-heterozygosity in budding yeast, showing non-independent mutation accumulation and systemic genomic instability.

Proceedings of the National Academy of Sciences · Oct 26, 2020Peer-reviewedGenetics

The bakerss yeast Msh4-Msh5 associates with double-strand break hotspots and chromosome axis during meiosis to promote crossovers

Krishnaprasad G. Nandanan, Ajith V. Pankajam, Sagar Salim, Miki Shinohara, Gen Lin, Parijat Chakraborty, Lars Michael Steinmetz, Akira Shinohara, Koodali T Nishant

The paper investigates the in vivo localization of Msh5 during meiosis in yeast, showing its association with DSB hotspots, chromosome axis, and centromeres, and its role in promoting crossover formation.

bioRxiv · Jul 24, 2020 · PreprintGenetics

The Neurospora crassa standard Oak Ridge background exhibits an atypically efficient meiotic silencing by unpaired DNA.

Dev Ashish Giri, Ajith V. Pankajam, Koodali T Nishant, Durgadas P. Kasbekar

The paper investigates MSUD efficiency in different Neurospora crassa genetic backgrounds, finding that the standard Oak Ridge background exhibits unusually efficient MSUD compared to other backgrounds.

G3 Genes Genomes Genetics · Mar 6, 2019Peer-reviewedGenetics

Mitotic systemic genomic instability in yeast

Nadia M. V. Sampaio, Aline Rodrigues-Prause, V. P. Ajith, Theodore M Gurol, Mary J Chapman, Ewa P. Malc, Parijat Chakraborty, Fabiana M. Duarte, Guadalupe M Aguirre, Pedro A. G. Tizei, Gonçalo Amarante Guimarães Pereira, Piotr A. Mieczkowski, Koodali T Nishant, Juan Lucas Argueso

The paper identifies systemic genomic instability in yeast, showing non-independent accumulation of loss-of-heterozygosity events across multiple chromosomes.

G3 Genes Genomes Genetics · Nov 1, 2018Peer-reviewedGenetics

mlh3 separation of function and endonuclease defective mutants display an unexpected effect on meiotic recombination outcomes

Najla Al‐Sweel, Vandana Raghavan, Abhishek Dutta, V. P. Ajith, Luigi Di Vietro, Nabila Reem Khondakar, Carol M. Manhart, Jennifer A. Surtees, Koodali T Nishant, Eric Alani

The paper identifies mlh3 alleles with distinct separation of function phenotypes in meiosis and DNA mismatch repair, revealing the role of protein-protein interactions in regulating Mlh1-Mlh3 activity.

PLoS Genetics · Aug 21, 2017Peer-reviewedGenetics