Celeste M. Nelson

This study uses spatial transcriptomics to map cell type organization during mouse lung development, identifying new mesenchymal clusters and dynamic changes in epithelial progenitors.

This study shows that TGFβ signaling regulates mesenchymal condensation, which physically displaces epithelial branches to maintain spacing during lung development.

The paper shows mitochondrial ATP patterns predict tissue folding during embryonic development by analyzing mitochondrial distribution and energy dynamics in epithelial cells.

The paper investigates morphogenesis in lizard lungs, finding that stress ball morphogenesis is conserved but luminal inflation varies, with apical constriction contributing to transitional chambers in veiled chameleons.

The paper investigates how high-fat circulating nutrients affect tumor growth and invasion in a 3D microfluidic model of triple-negative breast cancer, finding increased metabolic activity and MMP1 expression.

This study identifies a novel role for mesenchymal Vangl in airway elongation and widening during lung development, independent of the planar cell polarity complex.

The paper shows that airway smooth muscle in mouse lungs can exhibit a synthetic phenotype during development, which is sufficient for airway branching without contractile markers.

The paper shows Vangl in the pulmonary mesenchyme, not the airway epithelium, is critical for mesenchymal thinning and sacculation during lung development, independent of Celsr1.

This study determines individualized tryptase reference ranges by modeling BST levels based on TPSAB1 copy number, showing that elevated levels can indicate clonal myeloid neoplasms or be normal in HT carriers.

The paper identifies vascular smooth muscle as the developmental source of pulmonary smooth muscle in birds and shows PITX2 regulates this transition.

This study uses single-cell RNA-sequencing to show that pulmonary mesenchyme in embryonic mouse lungs lacks distinct progenitors and instead forms a continuum of cell identities regulated by Wnt signaling.