Katharine Goodwin

Mapping embryonic mouse lung development using enhanced spatial transcriptomics

This study uses spatial transcriptomics to map cell type organization during mouse lung development, identifying new mesenchymal clusters and dynamic changes in epithelial progenitors.

Patterns of Mitochondrial ATP Predict Tissue Folding

The paper shows mitochondrial ATP patterns predict tissue folding during embryonic development by analyzing mitochondrial distribution and energy dynamics in epithelial cells.

Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo

This study shows that migrating mouse primordial germ cells face increasing physical confinement and DNA damage during their journey to the gonads.

Mesenchymal Vangl facilitates airway elongation and widening independently of the planar cell polarity complex

This study identifies a novel role for mesenchymal Vangl in airway elongation and widening during lung development, independent of the planar cell polarity complex.

Plasticity in airway smooth muscle differentiation during mouse lung development

The paper shows that airway smooth muscle in mouse lungs can exhibit a synthetic phenotype during development, which is sufficient for airway branching without contractile markers.

A vascular origin for pulmonary smooth muscle in the avian lung

The paper identifies vascular smooth muscle as the developmental source of pulmonary smooth muscle in birds and shows PITX2 regulates this transition.

Patterning the embryonic pulmonary mesenchyme

This study uses single-cell RNA-sequencing to show that pulmonary mesenchyme in embryonic mouse lungs lacks distinct progenitors and instead forms a continuum of cell identities regulated by Wnt signaling.

Zebrafish yolk syncytial nuclei migrate along a dynamic microtubule network

The paper analyzes yolk syncytial nuclear migration during zebrafish epiboly and finds nuclei move along a dynamically changing yolk microtubule network rather than being pulled vegetally.