Role of the NuRD complex and altered proteostasis in cancer cell quiescence
Qi Jiang, Michelle C. Ertel, Austin Arrigo, Sara Sannino, Jennifer L. Goeckeler-Fried, April Sagan, Betsy Ann Varghese, Daniel D. Brown, Wayne Stallaert, Adrian Lee, Amanda M. Clark, Jeffrey L. Brodsky, Hatice U. Osmanbeyoglu, Ronald J. Buckanovich
This study identifies NuRD complex downregulation and altered proteostasis in quiescent ovarian cancer cells and shows that targeting these mechanisms can synergistically kill cancer cells.
bioRxiv · Feb 10, 2025 · PreprintCancer Biology