Jeffrey L. Brodsky

An endoplasmic reticulum resident molecular chaperone, GRP170, prevents stress-induced glomerular injury

This study shows that GRP170 protects podocytes from stress-induced glomerular injury by modulating the UPR, as demonstrated in a podocyte-specific knockout mouse model.

Aicardi-Goutieres Syndrome Associated ADAR G1007R mutation dominantly induces neuroinflammation in mouse brain

This paper describes a mouse model with a human ADAR G1007R mutation that causes neuroinflammation and shows that deleting MDA5 can reverse brain inflammation.

Role of the NuRD complex and altered proteostasis in cancer cell quiescence

This study identifies NuRD complex downregulation and altered proteostasis in quiescent ovarian cancer cells and shows that targeting these mechanisms can synergistically kill cancer cells.

Optimization of the fluorogen-activating protein tag for quantitative protein trafficking and co-localization studies in S. cerevisiae

The paper optimizes fluorogen-activating proteins (FAPs) for use in S. cerevisiae to enable quantitative endocytic studies and co-localization analysis of proteins.

Genome mining yields new disease-associated ROMK variants with distinct defects

The paper identifies new disease-associated ROMK variants using genomic databases and computational tools, revealing distinct molecular defects in protein folding and function.

Predicting protein targets for drug-like compounds using transcriptomics

The paper develops a pipeline to predict protein targets for drug-like compounds using transcriptomics and machine learning, achieving 26% top-10 accuracy on FDA-approved drugs.