Author

Ronald J. Buckanovich

University of PittsburghORCID 0000-0002-5665-9790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Nadine HempeliD· 3 shared Allison C. SharrowiD· 2 shared Amal Taher ElhawiD· 2 shared Amanda M. ClarkiD· 2 shared Huda Issa AtiyaiD· 2 shared Katherine M. AirdiD· 2 shared Lan Gardner CoffmaniD· 2 shared Adrian LeeiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Nadine HempelORCID

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Author profile →

6 papers

Recent·Most cited

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Amal Taher Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, Alexa L. Mattheyses, Aidan R. Cole, Yeon Soo Kim, Huda Issa Atiya, Mohamed Trebak, , Nadine Hempel

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

Cancer Research · Apr 16, 2026Peer-reviewedCancer Biology

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

Geyon L. Garcia, Taylor J. Orellana, Grace Gorecki, Leonard G. Frisbie, Roja Baruwal, Swathi Suresh, Ester Goldfeld, Ian Beddows, I. P. MacFawn, Ananya K. Britt, Macy M. Hale, Amal Taher Elhaw, Brian Robert Isett, Nadine Hempel, Riyue Bao, , Lan Gardner Coffman

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

Cancer Discovery · Mar 14, 2025Peer-reviewedCancer Biology

Role of the NuRD complex and altered proteostasis in cancer cell quiescence

Qi Jiang, Michelle C. Ertel, Austin Arrigo, Sara Sannino, Jennifer L. Goeckeler-Fried, April Sagan, Betsy Ann Varghese, Daniel D. Brown, Wayne Stallaert, Adrian Lee, Amanda M. Clark, Jeffrey L. Brodsky, Hatice U. Osmanbeyoglu, Ronald J. Buckanovich

This study identifies NuRD complex downregulation and altered proteostasis in quiescent ovarian cancer cells and shows that targeting these mechanisms can synergistically kill cancer cells.

bioRxiv · Feb 10, 2025 · PreprintCancer Biology

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer.

Santiago Panesso-Gómez, Alexander J. Cole, Alyssa M. Wield, Vivian I. Anyaeche, Jaynish S. Shah, Qi Jiang, Tonge Ebai, Allison C. Sharrow, George C. Tseng, Euisik Yoon, Daniel D. Brown, Amanda M. Clark, Scott D. Larsen, Ian Eder, David M. Gau, , Ronald J. Buckanovich

This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.

bioRxiv · Nov 15, 2024 · PreprintCancer Biology

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

Allison C. Sharrow, Emily Megill, Amanda J Chen, Afifa Farooqi, Naveen Kumar Tangudu, Apoorva Uboveja, Stacy C. McGonigal, Nadine Hempel, Nathaniel W. Snyder, Ronald J. Buckanovich, Katherine M. Aird

This study shows that ACSS2-mediated acetate conversion to acetyl-CoA promotes quiescence in ovarian cancer cells, linking metabolic reprogramming to therapeutic resistance.

Molecular Metabolism · Sep 19, 2024Peer-reviewedCancer Biology

The Genomic Landscape of Centromeres in Cancers

Anjan K. Saha, Mohamad Mourad, Mark H. Kaplan, Ilana Chefetz, Sami N. Malek, Ronald J. Buckanovich, David M. Markovitz, Rafael Contreras-Galindo

The paper quantifies centromere sequence heterogeneity in cancer using targeted PCR, identifies reductions in centromeric markers, and detects gene conversion events in pericentromeric regions.

Scientific Reports · Aug 2, 2019Peer-reviewedGenomics