Author

Alexander E.P. Loftus

University of EdinburghORCID 0000-0002-0013-1532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Margaret C. FrameiD· 2 shared A. R. S. BlackiD· 1 shared Ajitha RajaniD· 1 shared Alan SerrelsiD· 1 shared Alexander Walker· 1 shared Amy Broeders· 1 shared Anabel Martinez LyonsiD· 1 shared Andreea GrãdinaruiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Margaret C. FrameORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 26, 2025

FAK inhibitor treatment systemically regulates the glioblastoma immune environment via blocking monocyte trafficking

Emily R. Webb, A. R. S. Black, Giovana Carrasco…·Valerie G. Brunton

This study shows that systemic FAK inhibition reduces immunosuppressive macrophages in glioblastoma by blocking monocyte trafficking, enhancing T cell activity and improving survival in a mouse model.

DOI 10.1101/2025.11.26.690731

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintApr 21, 2025

Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.

Alexander Walker, Paula Olaizola, Euan Brennan…·Luke Boulter

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

1 citation

mousescRNA-seq

𝕏 PostBluesky