Mattia Miotto

The paper investigates how missense mutations in the SynGAP C2 domain affect membrane diffusion dynamics through molecular simulations and structural analysis.

This study designs an inhibitory peptide to prevent pathogenic dimerization of a misfolded antibody light chain by optimizing its sequence to maximize interface complementarity.

The paper presents three computational models to analyze fast-scan cyclic voltammetry data from mice, quantifying presynaptic dopamine kinetics and the role of synucleins in neurotransmission.

This study uses molecular dynamics and clinical data to show structural and dynamic differences between WTL and MBR SOD1 variants, linking these to distinct ALS clinical outcomes.

The paper measures asymmetric organelle partitioning in cancer cells and finds mitochondria and membrane lipids are asymmetrically distributed and correlated with cytoplasm apportioning.

The paper introduces a graph-theoretical framework to assess protein thermal stability using structural data, achieving 76% accuracy in distinguishing thermostable from mesostable proteins.