Giancarlo Ruocco

The paper uses molecular dynamics simulations to analyze SOD1 variants and finds that structural stability and conformational rigidity correlate with clinical severity in ALS.

The paper shows that chromatin condensates, regulated by MLL4, modulate nuclear mechano-sensing and prevent cGAS-STING activation in Kabuki Syndrome.

This study identifies a mechanism by which α-synuclein and γ-tubulin cooperatively regulate activity-evoked presynaptic microtubule nucleation to control dopamine release.

The paper investigates how missense mutations in the SynGAP C2 domain affect membrane diffusion dynamics through molecular simulations and structural analysis.

This study designs an inhibitory peptide to prevent pathogenic dimerization of a misfolded antibody light chain by optimizing its sequence to maximize interface complementarity.

This paper introduces 3DBonUS, a 3D bone printing method using ultrasound and microfluidic bioprinting to direct stem cell differentiation, showing increased osteogenic markers and mineralization.

This paper introduces a microfluidic-assisted 3D bioprinting system that enables precise control over cell compartmentalization and material composition for creating interconnected, functional tissue constructs.

This paper develops ATPS bioinks for 3D bioprinting that enable precise cellular compartmentalization and tissue regeneration.

The paper proposes a model for collective interactions in biomolecular condensates that describes dynamic clusters and their material properties.

This paper identifies low-complexity repeats as key drivers of RNA-RNA interactions and introduces RIME, a deep learning model that outperforms traditional methods in predicting these interactions.

The paper uses Pepper fluorescent RNA to visualize and study the dynamics of circRNAs and lncRNAs in live cells, revealing their interactions with pathological aggregates and stress granules.

The paper presents three computational models to analyze fast-scan cyclic voltammetry data from mice, quantifying presynaptic dopamine kinetics and the role of synucleins in neurotransmission.

This study uses molecular dynamics and clinical data to show structural and dynamic differences between WTL and MBR SOD1 variants, linking these to distinct ALS clinical outcomes.

The paper measures asymmetric organelle partitioning in cancer cells and finds mitochondria and membrane lipids are asymmetrically distributed and correlated with cytoplasm apportioning.