Thomas Schmidt

This study investigates how matrix stiffness influences spheroid invasion, collagen remodeling, and stress propagation in the ECM using 3D spheroids and stress sensors.

This study investigates altered mechanobiology in PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, finding increased traction forces and altered motility and invasion.

This study shows p130Cas modulates cellular force exertion by localizing to focal adhesions based on substrate stiffness, influencing mechanosensing and force dynamics.