Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability
Colin M. McCrimmon, Daniel Toker, Marie Pahos, Qing Cao, Kevin Lozano, Jack J. Lin, Jack M. Parent, Andrew M. Tidball, Jie Zheng, László Molnár, István Módy, Bennett G. Novitch, Ranmal Aloka Samarasinghe
This study uses human brain assembloids to model how a genetic epilepsy syndrome affects cortical and hippocampal networks differently, revealing distinct dysfunction patterns.
Cell Reports · Sep 1, 2025Peer-reviewedNeuroscience