This study uses human brain assembloids to model how a genetic epilepsy syndrome affects cortical and hippocampal networks differently, revealing distinct dysfunction patterns.

Cell Reports · Sep 1, 2025Peer-reviewedNeuroscience

A therapeutic small molecule lead enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice

Xiaofei Wei, Jesus J. Campagna, Barbara M. Jagodzinska, Dongwook Wi, Whitaker Cohn, Jessica Lee, Chunni Zhu, Christine Huang, László Molnár, Carolyn R. Houser, Varghese John, István Módy

The paper identifies a small molecule that enhances gamma-oscillations and improves cognition in Alzheimer's disease model mice by modulating GABAARs.

bioRxiv · Dec 4, 2023 · PreprintNeuroscience

Microglia undergo rapid phenotypic transformation in acute brain slices but remain essential for neuronal synchrony

Péter Berki, Csaba Cserép, Balázs Pósfai, Eszter Szabadits, Zsuzsanna Környei, Anna Kellermayer, Miklós Nyerges, Xiaofei Wei, István Módy, Kunihiko Araki, Heinz Beck, Kaikai He, Ya Wang, Zhaofa Wu, Miao Jing, , Ádám Dénes

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

bioRxiv · Apr 12, 2022 · PreprintNeuroscience

Identification of neural oscillations and epileptiform changes in human brain organoids

Ranmal Aloka Samarasinghe, Osvaldo A. Miranda, Jessie E. Buth, Simon A. Mitchell, Isabella Ferando, Momoko Watanabe, Thomas F. Allison, Arinnae Kurdian, Namie N. Fotion, Michael J. Gandal, Peyman Golshani, Kathrin Plath, William E. Lowry, Jack M. Parent, István Módy, Bennett G. Novitch

This study identifies neural oscillations and epileptiform changes in human brain organoids derived from MECP2 mutant patients using calcium imaging and extracellular recordings.

Nature Neuroscience · Aug 23, 2021Peer-reviewedNeuroscience