Johannes A. M. Merilahti

Direct aliquoting from a single heated well enables fully automated high-throughput thermal proteome profiling

The paper introduces DASH-PISA, a method for automated thermal proteome profiling that enables high-throughput compound screening by improving efficiency and reducing costs.

CYSTEINE-RICH RLK2 regulates development via callose synthase-dependent symplastic transport in Arabidopsis

This study shows CRK2 regulates plant development by modulating callose synthase activity, affecting symplastic transport and leading to starch accumulation and growth defects in Arabidopsis.

Queuosine modification mediates cold-active growth in Shewanella glacialimarina

This study shows that queuosine modification in Shewanella glacialimarina is essential for cold-active growth, as its deficiency leads to cold sensitivity and metabolic changes.

Keratin 7 protein presence in stool is indicative of active pediatric-onset inflammatory bowel disease

This study identifies keratin 7 (K7) protein in stool as a noninvasive biomarker for active pediatric-onset inflammatory bowel disease, showing high sensitivity and specificity.

YAP/TEAD drives treatment-induced adaptive immunosuppression in EGFR-mutant lung cancer

This study shows that DTP cells in EGFR-mutant lung cancer drive immunosuppression through YAP/TEAD activity, and co-targeting YAP/TEAD improves EGFR TKI therapy efficacy.

CRK2 controls the spatiotemporal distribution of QSK1 at plasma membrane during osmotic stress

This study shows CRK2 phosphorylates and sequesters QSK1 at the plasma membrane, preventing callose deposition at plasmodesmata under normal conditions, and its dephosphorylation allows QSK1 relocalization during osmotic stress.

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB inhibitor-induced phenotypes

This study uses phosphoproteomic analysis in zebrafish to show that ErbB inhibitors affect multiple signaling pathways, leading to similar physiological phenotypes.

LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

De Novo multi-omics pathway analysis (DMPA) designed for prior data independent inference of cell signaling pathways

DMPA is a de novo multi-omics method that discovers signaling pathways and regulatory relationships across omics data, outperforming existing methods in low-sample and zero-inflated datasets.