Diana M. Toivola

This study identifies lamin A/C as a regulator of intestinal inflammation and tumorigenesis by modulating immune and stromal cell functions in mouse models and human IBD biopsies.

This study identifies Scinderin as a regulator of Golgi actin remodeling that coordinates GLP-1 and insulin secretion, linking intracellular trafficking defects to glucose homeostasis and diabetes.

This study identifies keratin 7 (K7) protein in stool as a noninvasive biomarker for active pediatric-onset inflammatory bowel disease, showing high sensitivity and specificity.

This study examines colonic keratin expression in IBD, MC, and IBS, finding elevated levels in IBD, reduced in MC, and unchanged in IBS.

This study develops a genetic, colon-specific mouse model of colorectal cancer driven by K8 and Apc loss, showing increased tumorigenesis and reduced K8 expression in human patients.

This study shows that Parp14 deficiency in mice worsens colitis by impairing epithelial barrier integrity and altering inflammation-related gene expression.