Author

Sarah Ann Thomas

King's College LondonORCID 0000-0002-0053-0154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Alice L. Fleckney· 2 shared Doaa Boshra FaragiD· 2 shared Khondaker Miraz RahmaniD· 2 shared Mehmet FidanboyluiD· 2 shared Sevda Tomova BoyanovaiD· 2 shared Suzanne ReevesiD· 2 shared Anna K. Breen· 1 shared Ariana P. GattiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersNeuroscience

Alice L. Fleckney

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5 papers

Recent·Most cited

Saturation kinetics and specificity of transporters for L-arginine and asymmetric dimethylarginine (ADMA) at the blood-brain and blood-CSF barriers.

Mehmet Fidanboylu, Sarah Ann Thomas

This study identifies the transporters and kinetic parameters for L-arginine and ADMA across blood-brain and blood-CSF barriers in mice, revealing complex transport mechanisms and potential implications for NO regulation.

PLoS ONE · Jun 11, 2025Peer-reviewedNeuroscience

An mTOR Inhibitor Discovery System Using Drug-Sensitized Yeast

Anna K. Breen, Sarah Ann Thomas, David Beckett, Matthew Agsalud, Graham Gingras, J. Andrew Williams, Brian M. Wasko

This paper develops a yeast-based system to identify TOR inhibitors, demonstrating high sensitivity and effectiveness in detecting known and novel compounds.

bioRxiv · Jan 3, 2025 · PreprintMolecular Biology

L-Arginine and asymmetric dimethylarginine (ADMA) transport across the mouse blood-brain and blood-CSF barriers: evidence of saturable transport at both interfaces and CNS to blood efflux.

Mehmet Fidanboylu, Sarah Ann Thomas

This study investigates the transport of L-arginine and ADMA across the blood-brain and blood-CSF barriers in mice, finding saturable transport and CNS-to-blood efflux of ADMA.

PLoS ONE · Oct 24, 2024Peer-reviewedNeuroscience

Interaction of amisulpride with GLUT1 at the blood-brain barrier. Relevance to Alzheimer's disease

Sevda Tomova Boyanova, Ethlyn Lloyd-Morris, Christopher Peter Corpe, Khondaker Miraz Rahman, Doaa Boshra Farag, Lee K. Page, Hao Wang, Alice L. Fleckney, Ariana P. Gatt, Claire Troakes, Gema Vizcay‐Barrena, Roland A. Fleck, Suzanne Reeves, Sarah Ann Thomas

This study investigates how amisulpride interacts with GLUT1 at the blood-brain barrier and how Alzheimer's disease affects this transport mechanism.

PLoS ONE · Oct 24, 2023Peer-reviewedNeuroscience

Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

Gayathri Nair Sekhar, Alice L. Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa Boshra Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves, Sarah Ann Thomas

This study shows that changes in BBB transporters OCT1, PMAT, and MATE1 in Alzheimer’s disease increase sensitivity to amisulpride.

Fluids and Barriers of the CNS · Dec 1, 2019Peer-reviewedNeuroscience