Brian M. Wasko

BUDDY is a web platform that streamlines the functional modeling of human missense variants using yeast orthologs, reducing bioinformatic preparation time and enabling non-experts to design experiments.

This paper develops a yeast-based system to identify TOR inhibitors, demonstrating high sensitivity and effectiveness in detecting known and novel compounds.

The paper analyzes lifespan variation in wild yeast isolates to identify genetic and environmental factors shaping replicative lifespan and cellular processes involved in aging.

The paper shows that loss of vacuolar acidity in yeast causes iron sulfur cluster defects and divergent iron homeostasis during aging.