De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function
Nils Bessler, Amber K. L. Wezenaar, Hendrikus CR Ariese, Celina Honhoff, Noëlle Dommann, Ellen J. Wehrens, Cristian Ruiz-Moreno, Thijs J M van den Broek, Raphaël V U Collot, Daan J. Kloosterman, Farid Keramati, Mieke M Roosen, Sam de Blank, Esmée J. van Vliet, Mario Barrera Román, , Anne C. Rios
This paper develops a human brainstem organoid model of H3.3K27M-altered DMG to study GD2 CAR T cell function and identify therapeutic targets.
Nature Cancer · Jan 5, 2026Peer-reviewedCancer Biology