Richard C. Clark

This study identifies ATRX deficiency as a driver of aberrant type I interferon signaling via cGAS-dependent transcriptional dysregulation in patients with cerebral white matter disease.

The paper conducts a Bayesian EWAS and GWAS of smoking using DNA methylation data from blood and brain tissues, identifying smoking-related loci and developing an epigenetic biomarker.

The paper annotates transcription start sites and enhancers in cattle using CAGE sequencing across multiple tissues and populations to improve genome annotation and inform breeding programs.

The paper shows de novo DNA methyltransferases in colorectal cancer target H3K36me3-marked CpG islands, similar to normal tissues, rather than sequence-specific CpG islands.

The paper performs a global analysis of transcription start sites (TSS) in the ovine reference genome using CAGE sequencing, identifying novel TSS and validating them with bisulfite sequencing.