Giovanni Signore

A sensitive fluorometric assay to detect aldo-keto reductase and carbonyl reductase activity based on a naphthaldehyde derivative

This paper introduces a fluorometric assay for detecting reductase activity using MONOL-41, showing improved sensitivity and lower detection limits compared to NADPH-based methods.

CLN5 deficiency impairs glucose uptake in Batten disease

This study develops a zebrafish model of CLN5 deficiency, revealing impaired glucose metabolism as a novel feature of NCL.

Metabolic-imaging of human glioblastoma explants: a new precision-medicine model to predict tumor treatment response early

This paper develops a functional precision medicine approach using metabolic imaging to predict glioblastoma treatment response early in ex-vivo organoids, identifying responder and non-responder groups and a new molecular signature.