Maciej M. Lalowski

The lipidome and proteome of high-density lipoprotein are altered in menopause

The paper analyzes HDL lipid and protein composition in pre-, peri-, and postmenopausal women, finding distinct differences in particle size and composition during perimenopause.

CLN5 deficiency impairs glucose uptake in Batten disease

This study develops a zebrafish model of CLN5 deficiency, revealing impaired glucose metabolism as a novel feature of NCL.

CX3CR1 modulates migration of resident microglia towards brain injury

This study shows that CX3CR1 deficiency enhances microglial migration towards brain injury, suggesting it as a potential therapeutic target for CNS injuries.

USP14 regulates pS129 α-synuclein levels and oxidative stress in human SH-SY5Y dopaminergic cells

This study shows that USP14 regulates pS129 α-synuclein and oxidative stress in SH-SY5Y cells by affecting proteasome activity and reducing ROS.

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible versus resistant male mice upon repeated social defeat

This study shows that a ketogenic diet promotes resistance to stress in mice by altering microglial morphology and lipid profiles in the hippocampus, with distinct effects in stress-susceptible and resistant mice.

Epicardial therapy with atrial appendage micrografts salvages myocardium after infarction

This study evaluates the effectiveness of atrial appendage micrografts delivered epicardially to salvage myocardium after infarction in a mouse model, showing reduced fibrosis and increased cardiac regeneration-associated proteins.