EYA1/EYA2 and EYA3/EYA4 act as stage-specific SIX cofactors in embryonic and adult regenerative skeletal myogenesis
Camille Viaut, Maud Wurmser, Edgar Jauliac, Laura Ben Driss, Stéphanie Backer, Rouba Madani, Fayez Issa, Iryna Pirozhkova, Athanassia Sotiropoulos, Helge Amthor, Pascal Maire
This study investigates the role of EYA1/EYA2 and EYA3/EYA4 in skeletal myogenesis, showing that EYA3/EYA4 are critical for adult muscle regeneration while EYA1/EYA2 are essential for embryonic development.
bioRxiv · May 22, 2026 · PreprintDevelopmental Biology