Chromatin Environment-Dependent Effects of DOT1L on Gene Expression in Male Germ Cells
Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy‐Radio, Lucía Álvarez-González, Guillaume Meurice, Aurora Ruiz‐Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi
This study shows that DOT1L has opposing effects on gene expression in mouse spermatogenesis depending on chromatin environment, repressing some genes and activating others, particularly on the X chromosome.
Communications Biology · Jan 28, 2025Peer-reviewedMolecular Biology