Author

Sophia M. Guldberg

Denali Therapeutics (United States)ORCID 0000-0002-0102-4341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Connie HaiD· 2 shared David A. JoyiD· 2 shared David TatarakisiD· 2 shared Gilbert Di PaoloiD· 2 shared Jason C. DugasiD· 2 shared Jung H. SuhiD· 2 shared Kathryn M. MonroeiD· 2 shared Neal S. Gould· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Connie HaORCID

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2 papers

Recent·Most cited

Chronic NLRP3 inflammasome activation drives neutrophil brain entry and interactions with microglia

Lukas L. Skuja, Sophia M. Guldberg, David A. Joy, Jason C. Dugas, Neal S. Gould, Roni Chau, David Tatarakis, Isabel A. Becerra, Cynthia Chau, Connie Ha, David Huynh, Hoang Ngan Nguyen, Lily Sarrafha, Elizabeth Wen Sun, Shan V. Andrews, , Gilbert Di Paolo

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

bioRxiv · Apr 23, 2026 · PreprintNeuroscience

GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction

Karthik Raju, David A. Joy, Sophia M. Guldberg, Kyla Germain, Neal S. Gould, Connie Ha, David Tatarakis, Jason C. Dugas, Sonnet S. Davis, Audrey G. Reeves, Shan V. Andrews, Tanya N. Weerakkody, Jung H. Suh, Gabrielly Lunkes de Melo, Ken Xiong, , Kathryn M. Monroe

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

bioRxiv · Mar 28, 2025 · PreprintNeuroscience