Author

David Huynh

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Jason C. DugasiD· 4 shared Robert G. ThorneiD· 4 shared David A. JoyiD· 3 shared Elysia Roche· 3 shared Hoang Ngan NguyeniD· 3 shared Isabel A. Becerra· 3 shared Johann ChowiD· 3 shared Joseph W. LewcockiD· 3 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Jason C. DugasORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chronic NLRP3 inflammasome activation drives neutrophil brain entry and interactions with microglia

Lukas L. Skuja, Sophia M. Guldberg, David A. Joy, Jason C. Dugas, Neal S. Gould, Roni Chau, David Tatarakis, Isabel A. Becerra, Cynthia Chau, Connie Ha, David Huynh, Hoang Ngan Nguyen, Lily Sarrafha, Elizabeth Wen Sun, Shan V. Andrews, , Gilbert Di Paolo

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

bioRxiv · Apr 23, 2026 · PreprintNeuroscience

Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules

Robert C. Wells, Padma Akkapeddi, Darren Chan, David A. Joy, Arash Moshkforoush, Roni Chau, Johann Chow, Gerald Maxwell Cherf, Ellen Y. T. Chien, Allisa J. Clemens, Michelle E. Pizzo, Ahlam N. Qerqez, Tiffany M. Tran, Isabel A. Becerra, Jason C. Dugas, , Kylie S. Chew

This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.

Cell Reports · Jul 22, 2025Peer-reviewedNeuroscience

Transferrin receptor-mediated transport at the blood-brain barrier is elevated in early development but maintained across adult aging

Vanessa O. Torres, Michelle E. Pizzo, Darren Chan, Jason C. Dugas, David Huynh, David A. Joy, Eric Liang, Lily Sarrafha, Isabel A. Becerra, Roni Chau, Kylie S. Chew, Johann Chow, Timothy Earr, Nathalie Khoury, Kendra J. Lechtenberg, , Y. Joy Yu Zuchero

This study investigates TfR-mediated BBB transport in mice across development and aging, finding elevated transport in early development and stability across adulthood, including in an AD model.

bioRxiv · Nov 12, 2024 · PreprintNeuroscience

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis, Matthew J. Simon, Rebekah L. Dial, Lizanne Nilewski, Robert C. Wells, Yinhan Zhou, Megan E. Afetian, Alfred E. Chappell, Kylie S. Chew, Johann Chow, Allisa J. Clemens, Claire B. Discenza, , Sarah L. DeVos

This paper demonstrates that systemically delivered OTV, a TfR-binding molecule, effectively transports ASO across the BBB, achieving widespread and sustained knockdown of target genes in the CNS of mice and non-human primates.

bioRxiv · Apr 25, 2023 · PreprintNeuroscience