Author

Karthik Raju

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 1 Assay:imaging· 1

Frequent Co-Authors

Thomas Christian SüdhofiD· 2 shared Alessandra SclipiD· 1 shared Amber Nabet· 1 shared Ao DongiD· 1 shared Audrey G. Reeves· 1 shared Connie HaiD· 1 shared David A. JoyiD· 1 shared David TatarakisiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Thomas Christian SüdhofORCID

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3 papers

Recent·Most cited

GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction

Karthik Raju, David A. Joy, Sophia M. Guldberg, Kyla Germain, Neal S. Gould, Connie Ha, David Tatarakis, Jason C. Dugas, Sonnet S. Davis, Audrey G. Reeves, Shan V. Andrews, Tanya N. Weerakkody, Jung H. Suh, Gabrielly Lunkes de Melo, Ken Xiong, , Kathryn M. Monroe

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

bioRxiv · Mar 28, 2025 · PreprintNeuroscience

Postsynaptic synucleins mediate vesicular exocytosis of endocannabinoids

Eddy Albarran, Yue Sun, Yu Liu, Karthik Raju, Ao Dong, Yulong Li, Sui Wang, Thomas Christian Südhof, Jun Ding

The paper identifies synucleins as essential for vesicular exocytosis of endocannabinoids, linking their role in Parkinson's Disease to synaptic plasticity.

bioRxiv · Oct 4, 2021 · PreprintNeuroscience

Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

Justin H. Trotter, Zahra Dargaei, Alessandra Sclip, Sofia Essayan-Perez, Kifayathullah Liakath‐Ali, Karthik Raju, Amber Nabet, Xinran Liu, Markus Wöhr, Thomas Christian Südhof

This study shows that neurexin-1 in astrocytes and neurons forms distinct nanodomains at synapses, enabling compartment-specific signaling that differentially regulates synapse function.

bioRxiv · Aug 21, 2020 · PreprintNeuroscience