Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis.
Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús Romero-Imbroda, Óscar Fernández, Laura Leyva, Fernando Rodrı́guez de Fonseca, Jerold J. M. Chun, Céline Louapre, Anne Baron‐Van Evercooren, Violetta Zujovic, Guillermo Estivill‐Torrús, Beatriz García-Díaz
This study shows that LPA1 receptor dysregulation in macrophages contributes to MS pathogenesis by promoting inflammation, with implications for therapeutic targeting.
Molecular Neurobiology · Sep 24, 2020Peer-reviewedNeuroscience