Fernando Rodrı́guez de Fonseca

Region-specific gene expression changes associated to oleoylethanolamide-induced attenuation of alcohol self-administration

This study investigates how OEA affects alcohol self-administration and gene expression in specific brain regions, finding region-specific changes in dopamine and cannabinoid receptor genes and immune responses.

Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis.

This study shows that LPA1 receptor dysregulation in macrophages contributes to MS pathogenesis by promoting inflammation, with implications for therapeutic targeting.