Paul Proost

Chemokine-binding all-D-CLIPS™ peptides identified using mirror-image phage display

This study identifies chemokine-binding all-D-CLIPS™ peptides using mirror-image phage display, showing sub-micromolar affinity and structural diversity.

Degradation rather than disassembly of necrotic debris is essential to enhance recovery after acute liver injury

This study shows that enzymatic degradation of necrotic debris improves recovery after liver injury, while disassembly strategies like peptide treatment or plasmin activation are less effective or harmful.

A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis

This study identifies CCR2 as critical for monocyte recruitment and BBB disruption in USUV encephalitis, showing therapeutic benefit from glucocorticoid treatment.

Complement activation at injury sites drives the phagocytosis of necrotic cell debris and resolution of liver injury

This study shows that complement proteins C1q and C3b promote phagocytosis of necrotic debris by neutrophils, monocytes, and macrophages, which is essential for liver injury resolution.