Arne Lindqvist

Cumulative microscopy reveals cellular states in fibroblasts from patients with genetic disorders

The paper introduces cumulative microscopy to analyze cellular states in fibroblasts from patients with genetic disorders, finding replication stress in CHH but not MUL.

CRISPR-PTM and CRISPR-VEIS: Multiplexed platforms for quantitative functional analysis of endogenous phosphosites

This paper introduces CRISPR-PTM and CRISPR-VEIS to quantitatively analyze endogenous phosphosite effects on cellular fitness and signaling, showing Y19 as a novel inhibitory site in the WEE1-CDK1 pathway.

Wee1 inhibition decouples Cdk1 and Plk1 activities: a role for gradual Cdk1 activation throughout G2 phase.

This study shows that gradual Cdk1 activation during G2 phase coordinates mitotic factor production and CDK1/PLK1 activation, and that WEE1 inhibition disrupts this coordination.

An ATM/Wip1-dependent timer controls the minimal duration of a DNA-damage mediated cell cycle arrest

The paper identifies an ATM/Wip1-dependent timer mechanism that determines the minimal duration of DNA-damage-induced cell cycle arrest.