Author

Ryan A. McClure

Chan Zuckerberg Biohub ChicagoORCID 0000-0002-0163-9290Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Biochemistry· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amber C. LennoniD· 3 shared Amy E. HerriD· 2 shared Cyril DeroyiD· 2 shared Maya M. OvertoniD· 2 shared Abdalla M. AbdrabouiD· 1 shared Adam Banlasan· 1 shared Alanur Tutar· 1 shared Aly Azeem KhaniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioengineering

Amber C. LennonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Same-cell mapping of epigenetic regulatory state to functional proteomic output

Xin Wang, Md Nazibul Islam, Cyril Deroy, Maya M. Overton, Ana E. Gomez Martinez, Trinh Lam, Anna Fomitcheva Khartchenko, Ryan A. McClure, Amber C. Lennon, Nadine Goldhammer, Julia Ye, Amy E. Herr

Proteo-Seq links chromatin accessibility and proteomic output in the same cell, revealing new protein-defined states in breast cancer cells.

bioRxiv · Oct 16, 2026 · PreprintBioengineering

Arrayed hydrogels pair whole-cell imaging with single-cell mass spectrometry proteomics

Maya M. Overton, Cyril Deroy, Eileen Wang, Amber C. Lennon, Joshua Eric Elias, Ryan A. McClure, Amy E. Herr

This paper introduces a platform called ProteoParcel that combines whole-cell imaging with single-cell mass spectrometry proteomics for breast cancer cells.

bioRxiv · Sep 9, 2026 · PreprintBioengineering

AI-Guided CRISPR Screen Accelerates Discovery of New Drug Targets

Chenlin Zhao, Mushaine Shih, Sharif Ahmed, Steven Song, Amber C. Lennon, Julia M. Mayes, Mengqi Jonathan Fan, Pei-Ying Lo, Jason F. Perera, Alanur Tutar, Andrew Kang, Elizabeth Warren, Ryan A. McClure, Aly Azeem Khan, Shana O. Kelley, Abdalla M. Abdrabou

This study uses a CRISPR screen and AI to identify new drug targets for psoriasis, finding ALOX5 and OXTR as promising candidates with validated therapeutic effects.

bioRxiv · Feb 28, 2026 · PreprintGenomics

An Automated High-throughput Affinity Capture-Mass Spectrometry Platform with Data-Independent Acquisition

Hui Jing, Paul L. Richardson, Gregory K. Potts, Sameera Senaweera, Violeta L. Marin, Ryan A. McClure, Adam Banlasan, Hua Tang, James E. Kath, Shitalben Patel, Maricel Torrent, Renze Ma, Jon D. Williams

This paper describes an automated AC-MS platform with DIA-MS for efficient kinase profiling and inhibitor selectivity assessment.

Journal of Proteome Research · Jan 27, 2025Peer-reviewedBiochemistry