Cancer BiologybioRxivPreprint
Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing
Ksenija Nesic, Franziska Geissler, Lijun Xu…·Matthew J. Wakefield
This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.
2 citations