Alexander Dobrovic

This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.

The paper generates a homozygous BRCA1-methylated OVCAR8 cell line using CRISPR editing to study meBRCA1 stability and PARPi resistance.

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

This paper identifies major sources of unwanted variation in cancer RNA-seq data and proposes a novel method to remove them using pseudo-replicates of pseudo-samples.

The paper introduces a new normalization method, RUV-III, for Nanostring nCounter gene expression data and evaluates its effectiveness across multiple datasets.

GRIDSS detects genomic rearrangements with high sensitivity and specificity using a positional de Bruijn graph assembler, outperforming existing methods on simulated and tumor data.