Author

Brett Liddell

QIMR Berghofer Medical Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alexander DobroviciD· 1 shared Anna DeFazioiD· 1 shared Australian Ovarian Cancer Study· 1 shared Cassandra J. VandenbergiD· 1 shared Clare L. ScottiD· 1 shared David D.L. BowtelliD· 1 shared Elizabeth L. KyraniD· 1 shared Fan ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander DobrovicORCID

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1 paper

Recent·Most cited

Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing

Ksenija Nesic, Franziska Geissler, Lijun Xu, Elizabeth L. Kyran, Sally Beard, Cassandra J. Vandenberg, Brett Liddell, Sam W.Z. Olechnowicz, Monique D. Topp, Orla McNally, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D.L. Bowtell, , Matthew J. Wakefield

This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology