Dante Poe

Distinct p21 dynamics drive alternative routes to whole-genome duplication through a common CDK4/6-dependent polyploid G0 state

The paper identifies two distinct p21-driven pathways to whole-genome duplication in breast cancer cells, both converging on a CDK4/6-dependent polyploid G0 state, and shows that CDK4/6 inhibitors can block WGD and enhance therapy efficacy.

LivecellX: Corrective Deep Learning for Object-Oriented Single-Cell Analysis in Live-Cell Imaging

LivecellX corrects segmentation and tracking errors in live-cell imaging using deep learning and provides tools for lineage reconstruction and dynamic analysis.

Transiently increased intercommunity regulation characterizes concerted cell phenotypic transition

The paper analyzes single-cell RNA sequencing data using transition path theory to study gene regulation during cell phenotypic transitions, finding increased intercommunity regulation and GRN frustration.