The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity.
Roshni A. de Souza, David Barneda, Donja Karimlou, Nick G.P. Bovee, Yuhan Zheng, Eveline J.E.M. Kahlman, Clara Lopes Novo, James K. Ellis, Bryony J. Leeke, Songyang Li, Megha Prakash Bangalore, Zijing Liu, Bebiana C. Sousa, Andrea F. Lopez‐Clavijo, Joop H. Jansen, , Véronique Azuara
The paper identifies a lipid metabolism-induced checkpoint during the exit of naïve pluripotency that ensures genome integrity through telomere regulation.
Cell Reports · Dec 1, 2025Peer-reviewedDevelopmental Biology