Anthony Lemieux

This study shows that DNMT1 overexpression in mouse embryonic stem cells causes global hypomethylation, focal hypermethylation, and increased methylome variability, with implications for cancer and therapeutic targeting.

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

This study examines sex-specific DNA methylation and gene expression changes in mouse placentas after early preimplantation alcohol exposure, finding significant differences in molecular profiles between male and female placentas.

This study identifies sex-based differences in DNA methylation and gene expression in late-gestation mouse placentas, revealing distinct patterns on the X chromosome and autosomes.