Daniel Sinnett

This study investigates how ThINKK-stimulated NK cells kill ALL cells via TRAIL and identifies TRAIL receptor expression as a biomarker for treatment sensitivity.

This study examines the dynamic changes in the immune microenvironment of paediatric solid tumours over time, revealing a shift toward immunosuppressive and tolerogenic states.

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

The paper identifies outlier RNA isoform expression as a method to detect clinically relevant genomic variants in B-ALL and other cancers with high sensitivity and specificity.

This study demonstrates real-time transcriptomic profiling using nanopore sequencing and a neural network classifier to classify childhood acute lymphoblastic leukemia subtypes efficiently.

This study shows that pre-implantation alcohol exposure causes sex-specific DNA methylation errors in fetal mouse forebrains, potentially contributing to FASD-related neurodevelopmental issues.

The paper investigates DNA methylation asymmetry between mouse placenta and embryo, identifying DMR subtypes and the role of DNMT3B and DNMT3A in establishing and maintaining these patterns.

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.