Serge McGraw

This study shows that DNMT1 overexpression in mouse embryonic stem cells causes global hypomethylation, focal hypermethylation, and increased methylome variability, with implications for cancer and therapeutic targeting.

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

This study examines sex-specific DNA methylation and gene expression changes in mouse placentas after early preimplantation alcohol exposure, finding significant differences in molecular profiles between male and female placentas.

This study identifies sex-based differences in DNA methylation and gene expression in late-gestation mouse placentas, revealing distinct patterns on the X chromosome and autosomes.

This study shows that pre-implantation alcohol exposure causes sex-specific DNA methylation errors in fetal mouse forebrains, potentially contributing to FASD-related neurodevelopmental issues.

The paper investigates DNA methylation asymmetry between mouse placenta and embryo, identifying DMR subtypes and the role of DNMT3B and DNMT3A in establishing and maintaining these patterns.

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.