Author

Elizabeth Elder

Centre Hospitalier Universitaire Sainte-JustineORCID 0000-0002-9139-3991Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anthony LemieuxiD· 2 shared Serge McGrawiD· 2 shared Daniel SinnettiD· 1 shared Guillaume BourqueiD· 1 shared Lisa‐Marie Legault· 1 shared Maxime CaroniD· 1 shared Nicolas Y. Gévry· 1 shared Noël J.‐M. RaynaliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Anthony LemieuxORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 24, 2026

DNMT1 overexpression disrupts DNA methylation homeostasis in mouse embryonic stem cells

Elizabeth Elder, Anthony Lemieux, Serge McGraw

This study shows that DNMT1 overexpression in mouse embryonic stem cells causes global hypomethylation, focal hypermethylation, and increased methylome variability, with implications for cancer and therapeutic targeting.

DOI 10.64898/2026.01.26.701550

mouseDNA methylation

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Cell BiologyNucleic Acids ResearchPeer-reviewedFeb 8, 2025

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

Elizabeth Elder, Anthony Lemieux, Lisa‐Marie Legault…·Serge McGraw

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

9 citations

mouseDNA methylation

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