Jessica Kalla

This study establishes a murine tumoroid biobank to identify oncogenic pathways and drug vulnerabilities in prostate cancer, finding that PTEN loss drives cancer pathways and that specific compounds inhibit tumor growth.

This study investigates how TGF-β affects colorectal cancer tumoroids, finding that aggressive KRAS mutations lead to partial EMT and increased invasiveness.

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

This study identifies biomarkers and trajectories of prostate cancer progression using bioinformatics fusion of weighted correlation network analysis and machine learning, finding the EZH2-TROAP axis as a key trajectory and 58 validated biomarkers.