Author

Daniel J. Sheward

Karolinska InstitutetORCID 0000-0002-0227-5636Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:Bayesian inference· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:large language model· 1

Frequent Co-Authors

Ben MurrelliD· 3 shared Adnane AchouriD· 1 shared Ainhoa Moliner-Morro· 1 shared Alec P. PankowiD· 1 shared Alexandra A. Abu-ShmaisiD· 1 shared Alexis K. JankeiD· 1 shared B. Martin Hällberg· 1 shared Beichen GaoiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersSynthetic Biology

Ben MurrellORCID

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4 papers

Recent·Most cited

Synthetic BiologyCell SystemsPeer-reviewedSep 1, 2025

Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2

Roy A. Ehling, Mason Minot, Max D. Overath…·Sai T. Reddy

This study uses synthetic coevolution to explore mutational trajectories between neutralizing antibodies and SARS-CoV-2 variants, revealing antagonistic and compensatory mutations.

10 citationstop 3%

proteomicsmachine learning (classical)

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BioinformaticsbioRxivPreprintDec 20, 2024

Generation of antigen-specific paired chain antibody sequences using large language models

Perry T. Wasdin, Nicole V. Johnson, Alexis K. Janke…·Ivelin S. Georgiev

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

3 citations

humanprotein sequence

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BioinformaticsbioRxivPreprintNov 28, 2020

Estimating the timing of HIV infection from unmutated sequences

Alec P. Pankow, Murray B. Christian, Natalie Smith…·Ben Murrell

This paper introduces a Bayesian method to estimate HIV infection timing from unmutated sequences, avoiding data curation and providing accurate results robust to complications like APOBEC hypermutation.

DOI 10.1101/2020.11.28.402271

humanDNA methylation

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MicrobiologybioRxivJun 2, 2020

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward…·Gerald M. McInerney

This paper identifies an alpaca nanobody that neutralizes SARS-CoV-2 by blocking the ACE2 receptor interaction.

DOI 10.1038/s41467-020-18174-5

proteomicsexperimental assay

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