Author

Petr Klimeš

Duke UniversityORCID 0000-0002-0232-9518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Assay:electronic health records· 3 Approach:experimental assay· 3 Approach:statistical model· 1

Frequent Co-Authors

Alyssa HoiD· 3 shared Birgit FrauscheriD· 3 shared Derek G. SouthwelliD· 3 shared John ThomasiD· 3 shared Kassem JaberiD· 3 shared Tamir AvigdoriD· 3 shared David CarlsoniD· 2 shared Hongyi YeiD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Alyssa HoORCID

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Author profile →

4 papers

Recent·Most cited

Sleep spindles stabilize human thalamocortical networks, inhibiting pathological disruptions

Kassem Jaber, Alyssa Ho, Hongyi Ye, Pilar Bosque‐Varela, Giovanna Aiello, Tamir Avigdor, Krishma Shenoy, Praveen Kumar Ramani, Lara Wadi, John Thomas, Petr Klimeš, Robert Mark Richardson, Derek G. Southwell, Peter Hadar, Sydney S. Cash, , Birgit Frauscher

This study investigates how sleep spindles interact with epileptic activity in thalamocortical circuits, finding bidirectional relationships and suggesting spindles stabilize network stability.

bioRxiv · Sep 19, 2026 · PreprintNeuroscience

Sleep fragmentation drives local, network-specific epileptic activity in human epilepsy

Birgit Frauscher, Alyssa Ho, Barbora Matoušková, Kassem Jaber, Tamir Avigdor, Erica Minato, John Thomas, Derek G. Southwell, Jeffery Alan Hall, David Carlson, Petr Klimeš, Laure Peter‐Derex, Sana Hannan

This study shows that sleep fragmentation increases local epileptic activity in specific brain regions without affecting broader network propagation.

bioRxiv · Sep 19, 2026 · PreprintNeuroscience

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction

Andrijana Angelovski, Hana Hříbková, Jiří Sedmík, Barbora Liscakova, Olga Švecová, Sona Cesnarikova, Kateřina Amruz Černá, Veronika Pospíšilová, Martin Král, Martina Kolajová, Petr Klimeš, Dáša Bohačiaková, Markéta Bébarová

This study uses patient-derived cerebral organoids to show that amyloid-β dysregulation correlates with network hyperexcitability in early Alzheimer's disease.

Cellular and Molecular Neurobiology · Jul 20, 2026Peer-reviewedNeuroscience

Thalamic Interictal Epileptic and Non-Epileptic Events during NREM Sleep in Patients with Focal Epilepsy: a Stereo-EEG Study

Hongyi Ye, Kassem Jaber, Alyssa Ho, Lingqi Ye, John Thomas, Xiaowei Xu, Cong Chen, Yi-He Chen, Guoping Ren, Matthew Moye, Tamir Avigdor, Irena Doležalová, Petr Klimeš, Prachi Parikh, Derek G. Southwell, , Birgit Frauscher

This study analyzes thalamic interictal events during NREM sleep in patients with focal epilepsy, finding associations between specific thalamic activity patterns and surgical outcomes.

EBioMedicine · May 14, 2026Peer-reviewedNeuroscience